No abstract

cautioned against the use of these medications in cases of diarrhea caused by highly inflammatory bacterial pathogens because of their potential association with complications such as toxic dilation of the colon or prolonged illness. This concern was based on the results of two RCTs: one investigating diphenoxylate/ atropine (Lomotil) therapy in shigellosis used in combination with oxolinic acid and the other investigating antimotility agent use in the treatment of diarrhea related to Clostridium difficile. The ACG guidelines did not specifically recommend for or against the use of loperamide in patients with dysentery.