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This paper provides an historical review of dissolution testing conducted by US Pharmacopeia, Inc. (USP). Current USP initiatives are also covered, including those designed to move USP to where it wants to be jive and I0 years from now. There will be a lot happening with dissolution testing in the next few years. It is expected that as many as 80% of USPS 500-plus dissolution requirements will go to a lower total analytical test load mode.

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