Alzheimer's disease is the most common in the elderly population. Due to its irreversible and progressive nature, it gained more attention for early management. In this regard, several new therapeutic targets, such as degrading neurotransmitter enzymes, amyloid cascade enzymes, and monoamine oxidases, have been explored. Inhibition of these targets with natural and synthetic compounds and dietary supplements has been traditionally exercised for decades in the etiology of AD. Secondary metabolites obtained from natural resources are in the trend to use against these targets. The purpose of this review is to provide a brief introduction to AD along with the related concept of several therapeutic compounds involved in the progression of the disease and its management using different natural compounds against selected targets.

The objective of this review to summarize the current status of information about the Alkhumra hemorrhagic fever caused by Alkhumra hemorrhagic fever virus an Arboviral infection. This virus was identified in Alkhumra district of Jeddah, Saudi Arabia in 1995 from a butcher patient. The infected individual develops symptoms febrile flu-like illness, hemorrhagic manifestations and less like encephalitis. Several cases have been reported from various locations of Saudi Arabia and a few from Egypt and is further expanding in tropical and subtropical regions of Western Asia. The virus is transmitted to human by direct contact to animal, raw meat, and biproducts as well as either tick or mosquito bites. Based on the recent status, a great concern of public health was raised with the AHFV epidemics and infection. Currently, there is no effective vaccine and antiviral therapeutics against AHFV. So, there is an urgent need to design and develop an effective preventive measure using interdisciplinary approach. This review will provide the status of research work based on the latest published information about AHFV. The provided information will be highly useful to design the effective preventive measures to control the disease in the Kingdom of Saudi Arabia.