Background-Optimal cancer care entails the coordination among multiple providers, continued follow-up and surveillance over time. The patient-centered care brings opportunities to improve the delivery of cancer care. The adoption of patient-centered oncology care (PCOC) is in its infancy. Evidence synthesis on the model's effectiveness is scant.Purposes-This is the first systemic review and meta-analysis on associations of PCOC with cancer patients' adverse healthcare utilization, cost, patient satisfaction and quality of care.Methods-Our study was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework. Quality appraisal was performed using Downs and Black's quality checklist. Study-level effect sizes of adverse healthcare utilization were computed using Cohen's D and summarized using forest plots. Funnel plots were constructed to examine publication bias.Results-Of 334 studies that were reviewed, ten met eligibility criteria and were included into the final analysis. Many included studies implemented almost all six of patient-centered care core attributes, plus three additional attributes that specifically addressed cancer patients' needs, including triage pathways, standardized and evidence-based symptom management, as well as support patient navigation. PCOC patients had lower utilization of inpatient care (standardized means difference [SMD] = −0.027, P= 0.049). Overall positive effect of PCOC on emergency department use was small and not significant (SMD= −0.023, P= 0.103). In terms of cost and *