In order to improve the safety performance of supertall buildings under earthquake, a seismic performance analysis method of double lines of supertall buildings based on a response surface optimization algorithm is proposed. Firstly, the structural performance indexes of super high-rise buildings are selected, and on this basis, the material constitutive model is constructed by the structural elastic-plastic analysis method to complete the seismic design of the first line of defense. Then, the response surface method is used to optimize the material constitutive model and complete the seismic design of the second line. Finally, the anticollapse limit state analysis method is used to determine the seismic performance of the double line of super high-rise building structures. The experimental results show that the proposed analysis method has high seismic performance, and the axial compression ratio of wall and column is always stable, in which the column is always at about 0.5 and the wall is always at about 0.26, which lays a foundation for the safety performance of super high-rise building structures under earthquake.