The aim of the research is to study the parameters of tolerance and adherence to antihypertensive therapy in patients with arterial hypertension and comorbidity in real clinical practice. Material and methods. The study included 138 adult patients (29% of men and 71% of women) with arterial hypertension and comorbidity receiving therapy in the cardiology department. The average age of the patients was 64.3 ± 12 years. Results. The mean Charlson index in our study was 3.97 ± 2.0 points (3.75 ± 2.3 points for men and 4 ± 1.9 points for women). Treatment adherence was low in 40% of men and 24.5% of women. The lowest rates of adherence were found to medical follow-up (85% in men and 83.6% in women) and lifestyle modifications (80% in men and 77.5% in women), the highest rates of adherence were to drug therapy (20 % for men and 18.4% for women). Significant correlations were found for all adherence categories with age and the number of drugs taken.Conclusion. Adherence to treatment in almost a third of the patients we surveyed was low. The lowest rates of adherence were found to medical support and lifestyle modifications, the highest were found to drug therapy. The factors influencing adherence, efficacy and tolerability of treatment includes age and the number of drugs taken.

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