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Hormonal factors impacting the vascular adaptions of the uteroplacental unit in non-complicated and complicated pregnancies are of interest. Here, 4 human placentas from women with and without preeclampsia were investigated for the presence of placental lactogen derived, antiangiogenic vasoinhibin. Western blotting and mass spectrometry of placental tissue revealed the presence of a 9 kDa placental lactogen derived vasoinhibin, the normal 22 kDa full-length placental lactogen, and a 28 kDa immunoreactive protein of undetermined nature. The sequence of the 9 kDa vasoinhibin includes the antiangiogenic determinant of vasoinhibin and could constitute a relevant factor in normal pregnancy and preeclampsia.