CONCLUSIONData presented show that the two-diameter column gives enhanced resolution of normally difficult separations for typical preparative and trace analyses. The two-diameter technique can be used for large samples without significantly increasing the time of analysis for both gases and liquids.This method may be applied to a combination gas chromatograph connected in series to a mass spectrometer. Frequently a trace component is too small to be identified by the mass spectrometer. The two-diameter column allows a much larger sample to be introduced into the gas chromatograph for a separation, without column overloading, and allows a satisfactory determination by the mass spectrometer. ACKNOWLEDGMENTThe author gratefully acknowledges the technical assistance of T. C. Harby in preparing the column used in these experiments.

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