The application of ceramics as bone substitutes is mainly due to their bioactivity property, presenting an ability to adhere to adjacent bone tissues. In the last decades the number of researches with bioactive ceramics in bone grafts has grown. The objective of the present study was to perform a literature review of the application of calcium phosphate ceramics in the biomedical fields. For this present study, 21 articles indexed indatabases, mainly through in PubMed and LILACS were selected and published between the years 2004 to 2019. Calcium phosphates are examples of bioceramics and are part of a group of combinations that constitute the natural structure of bones humans and teeth. The main reasons for calcium phosphate biomaterials standing out for bone replacement are their facility of use and biocompatibility. Current research indicates that the association of hydroxyapatite (HA) with tricalcium phosphate β (TCP-β) promotes better results regarding bone neoformation, showing promising results in the biomedical and biomaterials area, in the replacement of bone tissues. Synthetic bioactive ceramics have several applications and efficacy in the biomedical fields. HA and TCP-β have several properties scientifically demonstrated, the association of both being the result of the search for new materials and their improvement.

Objectives: This study was to carry out a prospective study on the patents reports of homeopathic formulations in the brazilian intellectual property bank, the National Institute of Industrial Property (INPI). Methods: This is a prospective research of patents referring to homeopathy products and medicines carried in May 2020. Searches were made for patents deposited with homeopathic purpose with the terms "homeopathy" and "homeopathic" from the first document until the last one deposited in 2019. We have found thirty-eight deposits with the search terms cited above, after exclusion of duplicates we selected twenty four. Results: Among the 24 patent reports selected, 15 (62.5%) were patents of invention. Among the classification of products, we highlight those of type A61K with 19 (79.1%). Twenty-four deposits were selected with the search terms "homeopathy" and "homeopathic". 20 (83.3 %) deposits with the term "homeopathic" and 4 (16.66%) to the term "homeopathy". Among the reports stand out patents of homeopathic formulations 14 (58.3%). There were a greater number of deposits in the years 2009 and 2013, both with 4 (16.6%) deposits. Conclusion: After analyzing patents on homeopathic products at the intellectual property bank in Brazil, it is concluded that most are related to new formulations. It can be seen that in Brazil the interest in relation to the protection of intellectual property in this topic is still small.