Could conventional endodontic treatment have an impact on oral health-related quality of life? There are still unresolved questions regarding this theme. In order to answer them, a systematic review on the available literature was undertaken to identify the methodological quality of and the risk of bias in all relevant studies. A broad search for articles was conducted, and only articles published before May 2016 were considered for review. The following portals were used: Pubmed, VHL (Medline, SciELO, Lilacs and BBO), Cochrane Library, and Web of Science. The keywords used for the search were 'quality of life' and 'root canal treatment. ' Furthermore, we included MeSH synonyms, related terms and free terms. Articles written in any language were included according to the PICOS approach (population, intervention, comparison, outcome and study design). After application of these eligibility criteria, selected articles were qualified by assessing their methodological quality and potential risk of bias. The initial search identified 302 references. After excluding duplicated abstracts and analysing the titles and abstracts, 6 were selected. One study was added via manual search of the reference lists. From these, 2 were eligible for quality assessment and were classified as being of high methodological quality and as having low risk of bias. Based on these studies, it can be concluded that conventional endodontic treatment improves oral health-related quality of life. However, these results should be interpreted with caution, due to the lack of important methodological details in the included studies. Additional investigations are warranted to provide more evidence on this subject. Keywords: Conventional endodontic treatment, oral health, quality of life, satisfaction, systematic review, therapeutics INTRODUCTIONThere is an increasing interest in the effect that dental treatments have on quality of life. The root canal treatment is an important part of this because endodontic problems are a common occurrence in dental practice and are a key reason patients seek dental care (1). Oral health-related quality of life (OHRQoL) is a multidimensional construct that reflects, among other things, the comfort of the individual when feeding and during sleep, social interactions, self-esteem and satisfaction with their oral health (2). The scientific dental community has made efforts to develop adequate instruments to evaluate the extent to which certain oral conditions occur within affected populations, and the effectiveness of health services in this area. Instruments measuring OHRQoL have become essential for measuring the population's perception of the impact of oral disorders on well-being, as well as for the evaluation of a treatment regimen's impact on the affected population´s quality of life (3). ABSTRACT HIGHLIGHTS• To date, evidence of the effectiveness of endodontic treatment and criteria of success have mainly been considered in terms of clinical outcome.• There is a lack of information of treatment outcomes from p...