A 49-year-old caucasian man was admitted to the Emergency Department for shortness of breath and cough. CT imaging showed bilateral a mild COVID-19 related pneumonia treated with O2 therapy and oral corticosteroids. Three weeks after discharge an HRCT find a giant bulla of the inferior lobe. The bulla was resected by VATS and the patient recovered completely. The development of the giant bulla in short time (less than two months) might be the result of SARS-CoV-2 infection. SARS-CoV-2 related pneumonia and corticosteroid therapy could be responsible for lung remodeling due to diffuse alveolar damage and later interstitial myofibroblastic proliferation.COVID-19 leads to pulmonary damages, which are still partially unknown and might result in development of bullae. In fit patient surgical treatment can be carried out safely.