In strcptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amyiin dose-dependently restored liver glycogen to normal levels. Significant mcreases over insulin-only therapy occurred with amylin doses of 10.30 and 100 ,ug/day, representing amylin: insulin ratios of 0.22.0.75 and 2.79.
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