Introduction: Coronavirus disease (COVID-19) is associated with a high incidence of thrombosis and mortality despite standard anticoagulant thromboprophylaxis. There is equipoise regarding the optimal dose of anticoagulant intervention in hospitalized patients with COVID-19 and consequently, immediate answers from high-quality randomized trials are needed. Methods: The World Health Organization's International Clinical Trials Registry Platform was searched on June 17, 2020 for randomized controlled trials comparing increased dose to standard dose anticoagulant interventions in hospitalized COVID-19 patients. Two authors independently screened the full records for eligibility and Study acronym or PI Trial ID Source registry Countries Date of registration Estimated study completion date COVID-HEP NCT04345848 ClinicalTrials.gov Switzerland

We performed a meta-analysis of randomized controlled trials comparing low-molecularweight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late ( ‡10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19; P 5 .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia. (Blood. 2016;127(13):1650-1655 Case presentation Case 1. A 34-year-old woman with 3 consecutive unexplained miscarriages wants to get pregnant again. Would she benefit from thrombophilia testing?Case 2. A 25-year-old woman with 1 unexplained pregnancy loss at 16 weeks' gestation is found to be heterozygote for the factor V Leiden mutation. She has no personal history of thrombosis. She asks whether taking low-molecular-weight heparin (LMWH) could prevent a second pregnancy loss.

Case presentation: A 26-year-old woman experienced persistent fever (39.5°C), chills, and right-lower-quadrant tenderness 3 days after caesarean delivery. A computed tomography (CT) scan of the abdomen and pelvis with contrast revealed enlargement of her right ovarian vein with an associated intraluminal filling defect. What is the best treatment of this patient?