The material presented in the article contains the results theoretical research, in terms of research and implementation in production technological design methods for the operational construction of mathematical models’ assembly processes of electronic devices and the choice of optimal parameters of their parts. This technique is based on the statistical principles of active planned experiment, which are currently widely used in various fields of science and technology. The use of these principles, in contrast to traditional methods of conducting a passive experiment and processing the results obtained in this case, allows to drastically reduce the time and material costs for a reliable mathematical description of complex physical laws that underlie the processes of compiling modern electronic devices and choosing the parameters of the parts included in them. The proposed methodology provides for a modification of the principles of an active planned experiment, which can be used when working with electronic devices consisting of independent (explained in the text of the article), in a certain sense, functional units or cascades, the mutual influence of which on the operation of the device is known in advance. It allows you to create such statistically determined models of radio electronic devices that can significantly reduce the labour intensity and economic costs necessary for setting up an experiment. The selection of primary factors included in an active planned experiment should be based on a thorough analysis of the principles of operation and design features of assembly objects, the physical essence of a particular technological process, as well as a study of the experience of mass production and the results of previous research in the relevant areas of technology. The success of the entire active planned experiment and the possibility of effective use of the obtained mathematical model in the design and technological preparation of production almost completely depend on the successful choice of factors. The purpose of the article is related to the development of a technique for the rapid construction of mathematical models of the assembly processes of radio-electronic devices and the selection of the optimal parameters of their parts.