As plantas produzem uma larga e diversa ordem de componentes orgânicos divididos em metabólitos primários e secundários. O objetivo deste estudo foi realizar a caracterização físico-química do fruto do cará moela (Dioascorea bulbifera). Analisou-se umidade, resíduos minerais, pH, sólidos solúveis totais, acidez total titulável e vitamina C e realizou-se ainda a caracterização dos metabólitos secundários (antocianinas e antocianidinas, flavonóis e xantonas, flavonas, chalconas e auronas, flavanonóis, leucoantocianidinas, catequinas (taninos catéquicos), fenóis, taninos pirogálicos, alcalóides, purinas, saponinas e polissacarídeos). Os resultados demonstraram que o cará moela possui 68,4% de umidade, 1,55% de cinzas, 2,94 mg/g de vitamina C, 4,1% de sólidos solúveis totais e um pH de 6,1. Foram encontrados resultados positivos para a presença de flavonas, catequinas (taninos catéquicos), alcalóides, saponinas e polissacarídeos.

Os transtornos alimentares (TA) representam um dos principais problemas de saúde pública, atingindo, principalmente, adolescentes e adultos jovens do sexo feminino, culminando com a insatisfação com a imagem corporal, busca pelo corpo ideal e vulnerabilidades psicológicas. O objetivo do estudo é analisar evidências na literatura em relação aos fatores psicológicos, sociais e econômicos no desenvolvimento de TA em jovens do sexo feminino. Trata-se de uma revisão integrativa da literatura, realizada por meio da pesquisa de artigos originais, com limite de 10 anos de publicação, em português, inglês e espanhol, indexados nas bases de dados de Scielo, Pubmed, Lilacs e Scopus. Foram encontrados 952 artigos na busca preliminar e 12 artigos foram incluídos, após o processo de seleção e remoção de artigos duplicados e inelegíveis. Constatou-se que alguns fatores influenciam no desenvolvimento e agravo dos TA, dentre eles, destaca-se a insatisfação corporal, autoestima, idealização da magreza, influência de familiares, amigos e mídia, uso indiscriminado de dietas, estado de humor, fatores psicológicos (depressão, ansiedade, impulsividade e estresse), idade, níveis socioeconômicos e fatores étnicos raciais. Conclui-se que os resultados confirmam que a insatisfação com a imagem corporal e os problemas psicológicos são os que mais influenciam no desenvolvimento do TA. Sendo assim, ressalta-se a necessidade da realização de mais estudos para maiores esclarecimentos sobre a temática.

There is scientific evidence that sulforaphane (SFN), a food component derived from cruciferous vegetables, has been shown to be effective in preventing breast cancer. The aim of the study is to analyze evidence in the literature regarding the effects of SFN on breast cancer cells. This is an integrative literature review conducted in accordance with the “PRISMA” recommendations, carried out by searching for original articles, with a limit of 10 years of publication, in English and Portuguese, indexed in the PubMed database, Science Direct and Cochrane. 1985 articles were found in the preliminary search and 13 were included, after the process of selection and removal of duplicate and ineligible articles. It was found that 69.2% (n = 9) of the studies demonstrated that the SFN reduced viability, 53.9% (n = 7) verified induction of apoptosis, 7.7% (n = 1) evaluated the expression of hTERT and found its inhibition after treatment. The expression of the pro-apoptotic gene BAX and the anti-apoptotic gene BCL-2 were evaluated in 38.46% (n = 5) of the studies where it was possible to verify that 23% (n = 3) reported BAX induction and 38, 46% (n = 5) reduced the level of BCL-2. It is concluded that the results reinforce the benefits of SFN as a compound with preventive effects in breast cancer. In spite of this, the need to conduct more research is highlighted, which allows further clarification on the proposed theme, as well as the question of dosage and improvement of clinical results.

No abstract

Chronic Kidney Disease (CKD) is an injury that causes progressive impairment of exocrine and endocrine renal functions. A very common complication is anemia, caused by reduced erythropoietin production, iron deficiency and inflammation. Evidence demonstrates that vitamin D has effects on anemia of inflammation, through the increase in erythrocytes and decrease in pro-inflammatory cytokines. This study aims to review the effects of vitamin D supplementation on 25(OH)D2 concentrations, on anemia markers and on PTH levels. This is an integrative review carried out through the search and selection of original publications, in english and portuguese, indexed in PubMed, Web of Science and Science Direct databases belonging to the 2010-2020 range. The results pointed to 25(OH)D2 concentrations compatible with normality after vitamin D supplementation. In five studies, there was no change in hemoglobin and PTH levels, and in four studies there was a reduction in the dose of EPO or erythroid stimulating agent, attributing such effect on the role of calcitriol as a substrate for bone marrow erythropoietic cells. The study concluded that vitamin D supplementation had beneficial effects for correction of 25(OH)D2 deficiency, however, it reinforces the controversy about the behavior of vitamin D on the improvement of anemia markers and PTH levels in patients with DRC. Therefore, it is suggested that the beneficial effect of vitamin D on anemia in renal patients may be independent of PTH suppression.