This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder. A case-cohort design was implemented using data from 10 US study sites participating in the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. The 1994 birth cohort included 253,347 study-site births with complete parental age information. Cases included 1,251 children aged 8 years with complete parental age information from the same birth cohort and identified as having an autism spectrum disorder based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. After adjustment for the other parent's age, birth order, maternal education, and other covariates, both maternal and paternal age were independently associated with autism (adjusted odds ratio for maternal age ≥35 vs. 25–29 years = 1.3, 95% confidence interval: 1.1, 1.6; adjusted odds ratio for paternal age ≥40 years vs. 25–29 years = 1.4, 95% confidence interval: 1.1, 1.8). Firstborn offspring of 2 older parents were 3 times more likely to develop autism than were third- or later-born offspring of mothers aged 20–34 years and fathers aged <40 years (odds ratio = 3.1, 95% confidence interval: 2.0, 4.7). The increase in autism risk with both maternal and paternal age has potential implications for public health planning and investigations of autism etiology.

A group of 155 parents and their preschool children attending Head Start reported on the children's exposure to community violence, level of distress symptoms, and behavioral problems. The behavioral correlates of exposure were found to differ according to exposure modality: internalizing problems were more likely in children who witnessed violence, and externalizing problems in those victimized by violence. Issues regarding self-reports by preschool children are highlighted, and clinical and research implications discussed.

This study explored developmental changes and effects of Down syndrome on mothers' structuring of their children's play. Mothers and their young children with Down syndrome (n = 28) were compared with socioeconomically matched samples of mothers and their mental age-matched (n = 28) and chronological age-matched (n = 28) typically developing children. Mothers of typically developing children exhibited more object demonstrations with their developmentally younger children, who exhibited less object play. Mothers of children with Down syndrome were more directive and supportive than were mothers of younger and older typically developing children, who did not differ in their frequencies of these behaviors. More maternal supportive object behavior was associated with more object play and vocalization by children with Down syndrome. Mothers and children in all 3 groups were contingently responsive to their partners' behavioral signals.

No abstract