Psychological stress, if sustained over an extended period of time can have deleterious effects on the body. Psychological stress has been implicated as risk indicators for periodontal disease. So, the aim of the current study was to determine the relationship of stress, anxiety and depression level and salivary IgA with periodontal disease. A total 30 patients who referred to periodontology included to the study and divided into 2 experimental groups. Group control patients do not suffer from any periodontal disease and patients CAL up 3 millimeters or more and BOP in upper teeth (case group). All cases were evaluated for stress, anxiety and depression level by DASS42 test. Salivary samples were obtained using spitting method and IgA level is determined with ELISA. Data was analyzed by 2 and Mendle-hazel tests. The patients suffering from periodontal disease were not encountering higher level of stress and anxiety (P=0.3). People suffering periodontal disease (86.7%) were depressed while 60% of people neither periodontal disease nor depressed (P=0.1). A signifi cant difference detected in salivary IgA level in control group (312.66+107.3) compared to case group (207.95+57.21) (P=0.001). Conclusion: these results suggested a correlation exists between incidence of the periodontal disease and immunity.