The children with Pierre Robin Sequence (PRS) have anatomical and physiological challenges of airway management. The children with PRS have difficult airway caused by micrognathia, glossoptosis, and cleft palate. The patients' airway management who have PRS is dificult and requires attention. Here we present a 5-year-old girl with PRS, admitted to our hospital for cleft palate repair surgery. She also had a history of traсheostomy. Otholaryngologists had to perform trachestomy for this operation. The patient had an uneventful operative and postoperative period. We wanted to discuss the difficulties of airway management of the children with PRS with this case report. Anaesthesiologists must be ready for the challenges and otholaryngologists, must also be ready to manage these difficult airways. In addition, bronchospasm and airway obstruction after extubation are very common complications, so careful postoperative monitoring should be performed.