With cytology for screening cervical cancer providing a successful reference, endometrial cancer screening has attracted more attentions recently. The objective of this study is to evaluate the application of endometrial sampler SAP-1 as a screening tool to detect endometrial cancer among postmenopausal women. From August 2018 to February 2021, 54 postmenopausal women were hospitalized for undergoing hysteroscopy examination. Before the procedure, endometrial samples were collected by the method of SAP-1. The histological results were compared with those by hysteroscopy sampling. The satisfactory rate for the endometrial specimen by SAP-1 sampling was 88.9%. The sensitivity, specificity and accuracy rate of SAP-1 sampling for diagnosing the cancer or precancerous lesions of endometrium were 87.5%, 100% and 97.9%, respectively. Among these patients, whether they had bleeding symptoms, endometrial thickening or intrauterine occupying lesions, risk factors for endometrial cancer or not, the diagnostic coincidence rate of SAP-1 sampling was over 96%, and the differences were not statistically significant (P>0.05). In conclusions, in postmenopausal women, SAP-1 sampling is an ideal screening method, regardless of whether the patients have bleeding symptoms, endometrial thickening or intrauterine occupying lesions, endometrial cancer risk factors. The diagnostic coincidence rate is quite high, but it still needs large sample study to verify.

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