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Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC 50 3.05 and 2.87 µg/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC 50 values of 3.18 and 5.22 µM, respectively.

Aurones and Isoaurones from the Flowers of Rosa damascena and Their Biological Activities. -New aurone (I) and new isoaurone (II), damaurones A and B, resp., (II) are isolated from the title rose together with five known compounds. Aurone (I) has significant potential anti-HIV-1 activity with therapeutic index above 80 and shows high cytotoxicities against the cell lines NB4 and MCF7. -(GAO, X.-M.; YANG, L.-Y.; HUANG, X.-Z.; SHU, L.-D.; SHEN, Y.-Q.; HU, Q.-F.; CHEN*, Z.-Y.; Heterocycles 87 (2013) 3, 583-589, http://dx.