The RLRs mediated viral recognition provided a potential molecular target for acute viral infections and andrographolide could ameliorate H1N1 virus-induced cell mortality. And the antiviral effects might be related to its inhibition of viral-induced activation of the RLRs signaling pathway.

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The Mixture of Shengmai Powder and Danshen Decoction could inhibit the process of myocardial fibrosis in the rat myocardium of DCM through multiple pathways and significantly delay the genesis and progress of DCM in hyperglycemic rats.

those of controls, p<0.05. The expression of IL-23 protein were also higher than those of controls, which in concordance with the changes of mRNA. Conclusions Our data show that local significantly increased levels of IL-23p19mRNA in myocardium and IL-23 may play a role in the pathogenesis of mice virus myocarditis. Objective To study the effect of the Mixture of Shengmai Pulvis and Danshen Decoction in protecting rats of the type 2 diabetic cardiomyopathy (DCM) model. Methods 42 SD rat models of DCM, established by combination of insulin resistance by a high-fat diet with intraperitoneal injection of high dose streptozotocin (50 mg/kg), were evaluated in the damage of the myocardium by ECG at the twelveth week after modelling, and the serum are analysed for blood glucose (GLU), cholesterol and triglyceride (TG); the content of the left cardiac ventricle myocardial collagen was quantified by Masson staining test; the level of myocardial cell apoptosis was tested with Tunel apoptosis kit; the damage extent of the myocardial subcellular structure was observed by electron microscopy; the expression levels of cardiac TSP-1, TGF-b1 and TRB-3 proteins were detected by immunohistochemistry, the changes of the expression levels of the cardiac TSP-1, A-TGFb1 and L-TGF-b1 protein were detected by Western blotting; and the changes of the mRNA expression levels of TSP-1 and TRB-3 were detected by real-time quantitative PCR. Results Compared with the control group, the rat blood glucose, cholesterol, triglycerides were significantly decreased; the myocardial tissue was less damaged and the collagen fibre content was reduced in the group of the Mixture of Shengmai Pulvis and Danshen Decoction; The myocardial sub-cellular structural damage in electron microscopy was to a lesser extent, the expression levels of the myocardial TSP-1, TGF-b1 and TRB-3 by immunohistochemical detection and the average expression levels of the myocardial TSP-1, A-TGFb1 and L-TGF-b1 by Western blotting were decreased; and the expression levels of TSP-1mRNA and TRB-3 mRNA by PCR detection were decreased than those of the control group. Conclusion The Mixture of Shengmai Pulvis and Danshen Decoction can inhibit through multiple pathways the process of myocardial fibrosis in the rat myocardium of diabetic cardiomyopathy, and significantly delay the formation course of diabetic cardiomyopathy in hyperglycemia rats. e0218 BIOLOGICAL CHARACTERISTICS RESEARCH OF STENT COATING WITH ZEDORAY CONSTITUENTS IN A PORCINE MODEL