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Prenatal diagnosis of simultaneous occurrence of double trisomy involving chromosomes 18 and X is extremely rare. We report on the prenatal diagnosis, genetic analysis and clinical manifestations of a fetus with both trisomy 18 and trisomy X. A 26‐year‐old, para 1 woman was referred for genetic counselling at 36 weeks' gestation with the sonographic findings of intrauterine growth retardation (IUGR), polyhydramnios, ventricular septal defect, and an enlarged cisterna magna. Both cordocentesis and amniocentesis revealed a consistent karyotype of 48,XXX,+18. Quantitative fluorescent polymerase chain reaction using polymorphic small tandem repeat markers specific for chromosomes 18 and X rapidly determined that both aneuploidies arose as a result of non‐disjunction in maternal meiosis II. Our case shows that two non‐disjunction events can occur not only in the same parent, but also in the same cell division. Our case also shows that double trisomy, 48,XXX,+18, can demonstrate an enlarged cisterna magna, IUGR and polyhydramnios in prenatal ultrasound. Copyright © 2000 John Wiley & Sons, Ltd.

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We describe the postoperative sonographic appearance of the uterus after successful use of simple square suturing for rapid control of profuse bleeding during cesarean section in a pregnant woman with uterine atony and placenta accreta. The serial sonograms initially showed decreased echogenicity in the compressed uterine area, but about 1 week after surgery, echogenicity of the compressed area returned to normal and, 2 weeks after surgery, patency of the uterine canal became evident. This report highlights the usefulness of this suturing technique for controlling such hemorrhage and the role of sonography in evaluating uterine status postoperatively.

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