A novel electrochemical non-enzymatic sensor for glucose and H2O2 based on metal organic framework (MOF)-derived cobalt-nickel bimetallic oxides (NiCo2O4) and gold nanoparticle (AuNPs) composite modified glassy carbon electrode (GCE) was fabricated in this paper. The electrocatalytic activity for glucose and H2O2 was investigated at the NiCo2O4/AuNPs/GCE using cyclic voltammetry (CV) and amperometric i-t technique. The catalytic currents for glucose and H2O2 are proportional to their concentrations in the range of 0.2 µM - 581 µM and 0.5 µM - 1774.5 µM, respectively. The corresponding limits of detection (LOD) were calcuated be 0.0081 µM and 0.181 µM for glucose and H2O2. Furthermore, the NiCo2O4/AuNPs/GCE shows excellent stability, reproducibility and anti-interference ability, and it has been successfully used to detect glucose in honey and fruits and H2O2 in lake water.

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