With the development of the social economy and the acceleration of economic globalization, human resources of enterprises have become an important factor restricting the development of enterprises. This paper creates an enterprise human resource management platform application based on twin network and mobile edge computing. By allocating computing and storage resources to the network edge close to users or data sources, mobile edge computing supports mobile to complete the computing offload of wireless access network applications. This process significantly reduces the end-to-end delay of the network and effectively reduces the processing load of the core network and data center. The simulation results can see that the average user benefit of all algorithms increases with the increase of network transmission speed and VCPU processing power. In addition to the introduction and popularization of information technology, the construction of enterprise human resources informatization also requires continuous and comprehensive monitoring and analysis of existing internal data, information, and data. The use of network communication technology to build a management information system, through information management, can significantly optimize and improve the efficiency of enterprise human resource management.