NC machine plays an irreplaceable role in the modern manufacturing because of its high machining processing accuracy, quality stable, flexibility. Through using the Renishaw ML10 laser interferometer detect the positioning accuracy and repositioning accuracy of X axis and Z axis of the HTC20 series of NC machine tools. According to the detection result compensate NC system to meet the machining accuracy requirement. The result shows that the error compensation of NC system is a effective method to improve the position accuracy of NC machine.