Diabetic foot ulcer has become a worldwide clinical medical challenge as traditional treatments are not effective enough to reduce the amputation rate. Therefore, it is of great social significance to deeply study the pathogenesis and biological characteristics of the diabetic foot, explore new treatment strategies and promote their application. Stem cell-based therapy holds tremendous promise in the field of regenerative medicine, and its mechanisms include promoting angiogenesis, ameliorating neuroischemia and inflammation, and promoting collagen deposition. Studying the specific molecular mechanisms of stem cell therapy for diabetic foot has an important role and practical clinical significance in maximizing the repair properties of stem cells. In addition, effective application modalities are also crucial in order to improve the survival and viability of stem cells at the wound site. In this paper, we reviewed the specific molecular mechanisms of stem cell therapy for diabetic foot and the extended applications of stem cells in recent years, with the aim of contributing to the development of stem cell-based therapy in the repair of diabetic foot ulcers.

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In order to save energy by broadening its application range, the influence of impeller trim on the performance of a twostage self-priming centrifugal pump was numerically studied. The hydraulic performance experiments and self-priming experiments were carried out. And the unsteady performance of pressure fluctuation and radial force in the pump was analyzed. The results show that with the increase in impeller trim quantity, the best efficiency point of the pump would move to the small flow rate condition. Under the design flow rate, when both the two stages of the impeller were trimmed by 6%, head of the pump was reduced by 13%, efficiency of the pump was as well decreased by 1.69 percentage points, and self-priming time was increased by 1.7%. Thus, impeller trim can be used to meet the operating requirements in the head range of 94-107 m. With the increase in impellers trim quantity, the pressure fluctuation in the positive channel of the radial guide vane and the volute was smaller, while the radial force on the wall of radial guide vane and volute was also smaller.