The effect of anisotropy of friction angle in natural deposited soil on the stability of soil slopes was studied in this paper. Stability analysis was performed on a uniform soil slope with anisotropic friction angle. Spencer’s method was used, and the variation of friction angle was assumed to be linear to the change of direction of the slip surface. It was shown that 7-10 percent of change in safety factor might achieve within a 10m-highed anisotropic soil slope. It was also found from the analysis that that frictional anisotropy had no obvious effect on the location of critical slip surface.