Considering the shortage of LEACH protocol, a novel dynamic multi-hop routing protocol named Balance Energy-efficient and Real-time with Reliable communication protocol based on Connected Dominant Set (BERR-CDS) is proposed in this paper. BERR-CDS protocol fully takes account of the energy consumption of an individual node and entire network, a rational transmission path from source node to sink node is searched, aiming at the network topology changes which are caused by the death of cluster head, the invalidation of cluster member nodes and new nodes joining, BERR-CDS designs the corresponding valid mechanism to respond, and it can rapidly adapt to the topology change of network. Simulation results show that BERR-CDS protocol has better performances in term of energy consumption, network lifetime and reliability, it is an ideal routing protocol in wireless sensor networks.