No abstract

Spin-labeled podophyllotoxins have elicited widespread interest due to their far superior antitumor activity compared to podophyllotoxin. To extend our prior studies in this research area, we synthesized a new generation of spin-labeled podophyllotoxin analogs via isocyanide multicomponent reactions and evaluated their cytotoxicity against four human cancer cell lines (A-549, DU-145, KB and KBvin). Most of the compounds exhibited potent cytotoxic activity against all four cell lines, notably against the drug resistant KBvin cancer cell line. Among the new analogs, compounds 12e (IC50: 0.60–0.75 µM) and 12h (IC50: 1.12–2.03 µM) showed superior potency to etoposide (IC50: 2.03 – >20 µM), a clinically available anticancer drug. With a concise efficient synthesis and potent cytotoxic profiles, compounds 12e and 12h merit further development as a new generation of epipodophyllotoxin-derived antitumor clinical trial candidates.

No abstract

This work shows that ribavirin merits further study as a lead compound in a novel class of potential insect control agents or for managing field populations of Lepidoptera pests on cruciferous crops.

A new generation of spin--labeled podophyllotoxin analogues are synthesized and evaluated for their cytotoxicity against four human cancer cell lines. Compounds (IVd) and (IVe), the most promising derivatives, show superior potency compared to the clinically used drug etoposide. -(KOU, L.; WANG, M.-J.; WANG, L.-T.; ZHAO, X.-B.; NAN, X.; YANG, L.; LIU, Y.-Q.; MORRIS-NATSCHKE, S. L.; LEE*, K.-H.; Eur. J. Med. Chem. 75 (2014) 282-288, http://dx.