No abstract

No abstract

Background Extranodal natural killer/ T‐cell lymphoma (ENKTL) is a rare malignant tumor. This study aimed to develop a predictive nomogram and a web‐based survival rate calculator for dynamically predicting the survival of patients with sinonasal ENKTL (SN‐ENKTL). Methods This study investigated patients (n = 134) with SN‐ENKTL who had been initially treated in our hospital between Jan 2008 and Dec 2016. The patients were randomly divided into training and validation cohorts, in a 7:3 ratio. Independent prognostic factors were identified and integrated to build a predictive nomogram and a web‐based calculator using the Cox‐regression model. The nomogram was evaluated by consistency index and calibration curve. Results Age, lactate dehydrogenase, hemoglobin, Epstein–Barr virus DNA, and Ann Arbor stage were identified as independent risk factors. We constructed a predictive nomogram for survival and a web‐based calculator (https://taiqinwang.shinyapps.io/DynNomapp/). Conclusion This study developed a prognostic model and a web‐based calculator specifically focused on SN‐ENKTL for otolaryngologists to use to facilitate timely treatment decisions for the disease. Level of Evidence 4 Laryngoscope, 133:1645–1651, 2023

Objective To analyze frequency-specific hearing results surgery for chronic ear diseases, in relation to various surgical factors. Study design Retrospective cohort study. Setting Tertiary referral centre. Participants A total of 173 patients with chronic ear diseases who underwent surgical management at our hospital. Main outcome measures Air conduction threshold (AC), bone conduction threshold (BC), and air-bone gap (ABG) were tested at 250, 500, 1000, 2000, and 4000 Hz, respectively. Frequency-specific results were investigate in relation to various surgical factors. Results The radical mastoidectomy group and tympanoplasty group significantly improved in AC changes at every frequency. In the tympanoplasty group, ABG at all frequencies except 4,000 (P =.069) significantly improved. AC improved at low and mid frequencies when ossicular reconstruction was conducted. Different tympanic membrane repair materials showed significant improvement in AC at all frequencies. In all groups, BC data revealed significant improvements at 500, 1000 and 2000 Hz. Conclusions The hearing improved significantly postoperatively in AC and ABG test, mainly at low and mid frequencies. The BC improved significantly at 500-2000Hz.

BackgroundTo explore the clinical and laboratory features, therapy and prognosis of Kikuchi–Fujimoto disease (KFD) in the cervical region.MethodsWe retrospectively reviewed the medical records of 134 patients who were diagnosed and treated with KFD from January 2000 to May 2022 in Fujian Medical University Union Hospital (Fujian, China). Their clinical characteristics, affected lymph node size, imaging examinations, and laboratory study results were analyzed.ResultsThe mean patient age was 24.9 years, and the male–female ratio was 1:1.73. Fever (55.2%, n = 74) was the most common clinical manifestation. Leukopenia (49.3%) was the commonest reported laboratory abnormality. A majority (65.7%) of the 134 patients presented with bilateral nodal involvement.ConclusionKFD should be considered as a possible diagnosis in a female patient under the age of 30 presenting with cervical lymphadenopathy, fever, leukopenia, and elevated LDH.Level of Evidence4.