Objective: Assurance of patient safety to realize the quality of health services is the responsibility of all health workers, especially nurses. Improving patient safety can reduce the risk of nosocomial infections and prevent the negative effects of nursing actions. The application of patient safety is still low due to several aspects, namely communication errors (57.7%), safety and service quality (57.4%), open communication (54.4%), management support (53.8%), and the work environment. (28.4%). An unfavorable work environment for the professional practice of nursing harms the quality of nursing care and patient safety. Methods: Analyzed the relationship between the nurse's work environment and patient safety at Mitra Sejati General Hospital, Medan. Methods: This research is a correlational analytic descriptive study with a cross-sectional approach. The study population was all nurses in the inpatient room at Mitra Sejati General Hospital, Medan, totaling 200 nurses. The sampling technique used was total sampling, by setting inclusion criteria. The study wascarried out from March to July 2022. Data analysis was carried out univariate and bivariate using the chi-square test. Results: most of the respondents stated that patient safety was well implemented (56%) and the work environment was good (64.5%). There is a significant relationship between the nurse's work environment and patient safety, p-value = 0.005. Conclusion: A good working environment for nurses ensures the optimal implementation of patient safety. Therefore, the hospital management contributes to supporting a conducive working environment for nurses by involving nurses in decision-making related to the development of nursing services, improving the ability of nurses, fulfilling nurse resources according to the required expertise

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The low awareness of nurses to carry out nursing actions causes nurses to be very vulnerable to transmission of infection because nurses in providing nursing care to patients will have direct contact with blood and body fluids. Universal precautions require health workers to treat all patients equally using universal precautions regardless of the disease. The purpose of this study was to determine the relationship between the knowledge of nurses about Universal Precaution and the prevention of Nosocomial Infections at the Royal Prima Prima Hospital in Medan. This type of research is analytic with a cross-sectional design. The population in this study were all nurses in the ICU, NICU, PICU, and inpatient disease rooms and postoperative rooms as many as 58 people. Sampling in this study was to use a saturated sampling of 58 people. The results of the study with the results of the chi-square test with a degree of significance (α) = 0.05 and df = 4 obtained the calculation results, namely X²count 16.948 > X²table 9.488 and p-value = 0.002, then Ha is accepted, namely there is a relationship between nurses' knowledge about Universal Precautions and Nosocomial infection prevention measures. In conclusion, there is a relationship between nurses' knowledge of Universal Precaution and Nosocomial Infection prevention measures in hospitals. It is expected that respondents will increase their knowledge about Universal Precautions so that preventive measures are carried out properly and in accordance with standards so that Nosocomial Infections can be prevented