Background: Severe sepsis is a sepsis leading to organ dysfunction. It has rapid progression, multiple organ damage and high mortality. Patients and Methods: Prospective study was performed on 78 patients diagnosed clinically severe sepsis, hospitalized and treated at the ICU of the Dak Lak General Hospital, from April, 2016 to June, 2017. Results: The mean age was 56.55 ± 18.40 years. The rate of positive blood cultures was 57.7%, the majority of bacteria isolated were Staphylococcus aureus, E. coli and Klebsiella pneumonia. 62.8% of patients recovered from the disease, 37.2% died. Mortality rates associated with respiratory, skin- mucosal and gastrointestinal sources were 46.7%, 42.9% and 36.4%, respectively. The high mortality rate related to factors such as primary sources of infection, age (0.0325), respiratory failure (p < 0.001), multiple organ failure (p=0.0015), APACHE II score (mean: 22.83 ± 8.15 (p < 0.0001). Conclusions: The common bacteria causing severe sepsis were Staphylococcus aureus, E. coli and Klebsiella pneumonia. Factors related to mortality were age, male, respiratory failure, multiple organ failure, APACHE II score. Key words: severe sepsis, treatment, Dak Lak General hospital