The development and regeneration of the bone are tightly regulated by mechanical cues. Multiple cell types, including osteoblasts, osteocytes, osteoclasts, mesenchymal stem cells (MSCs), and recently found skeletal stem cells (SSCs), are responsible for efficient bone development and injury repair. The immune cells in the environment interact with bone cells to maintain homeostasis and facilitate bone regeneration. Investigation of the mechanism by which these cells sense and respond to mechanical signals in bone is fundamental for optimal clinical intervention in bone injury healing. We discuss the effects of exercise programs on fracture healing in animal models and human patients, which encouragingly suggest that carefully designed exercise prescriptions can improve the result of fracture healing during the remodeling phase. However, additional clinical tracing and date accumulation are still required for the pervasive application of exercise prescriptions to improve fracture healing.

As early as the 1990s, with the popularization and development of computer technology, many traditional industries applied computer technology to daily production, and both the products themselves and the production mode changed greatly. The transformation of the 3D patterns is the most striking, and the appearance of computer technology makes pattern design more diverse and production more large-scale. In other countries, computers have been widely used in all aspects of the design industry. Both 2D and 3D pattern design can't be separated from the application of computer technology, which makes the computer 3D technology constantly improved. As a branch of computer-aided design, computer pattern design is increasingly used in mural painting, carpet design, the textile industry, etc. At present, with the expansion of the work scope of pattern designers, the complexity of their work is getting higher and higher, and the division of labor is more precise. However, due to the limited knowledge and ability of individuals, complex patterns can't be completed by a single person. Generally, many people are needed to cooperate. In addition, due to the decentralization and internationalization of many companies and organizations, their designers are often scattered geographically, so it is urgent to support multi-user collaborative pattern design. Computer-supported multi-user collaborative pattern design system is a typical application of CSCW technology in the field of pattern design.

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