Persistent infection with one or more highly oncogenic human papillomaviruses (HPVs) or high-risk-HPV (HR-HPV) is necessary but not a sufficient aetiological agent for the development of cervical neoplasia. A number of viral, host, environmental and behavioural factors are suggested to be associated with the progression of cervical disorder. This study aimed to evaluate the impact of environmental and behavioural cofactors on the development of cervical disorders in HR-HPV-infected women in Serbia. A total of 541 women have been tested by PCR for the presence of HPV on the cervix. HPV genotypes were determined by direct DNA sequencing. Women identified as HR-HPV-positive were further classified into four subgroups according to their cytological status. All relevant information about demographical and behavioural factors was obtained by interviewer-based questionnaire. A number of analytical and descriptive statistical methods were used for processing the data. The cofactors found to be of significance for the progression of cervical disease were older age, body mass index >25, lower educational level, long-term smoking, previous genital infections and cervical interventions. On the other hand, condom use was found to have a protective role. Information about these cofactors might be very important for the development of more efficient cancer prevention programmes and promotion of anti-HPV vaccination.

Background. This experimental study evaluates fetal middle cerebral artery (MCA) circulation after the defined prenatal acoustical stimulation (PAS) and the role of cilia in hearing and memory and could explain signal transduction and memory according to cilia optical-acoustical properties. Methods. PAS was performed twice on 119 no-risk term pregnancies. We analyzed fetal MCA circulation before, after first and second PAS. Results. Analysis of the Pulsatility index basic (PIB) and before PAS and Pulsatility index reactive after the first PAS (PIR 1) shows high statistical difference, representing high influence on the brain circulation. Analysis of PIB and Pulsatility index reactive after the second PAS (PIR 2) shows no statistical difference. Cilia as nanoscale structure possess magnetic flux linkage that depends on the amount of charge that has passed between two-terminal variable resistors of cilia. Microtubule resistance, as a function of the current through and voltage across the structure, leads to appearance of cilia memory with the “memristor” property. Conclusion. Acoustical and optical cilia properties play crucial role in hearing and memory processes. We suggest that fetuses are getting used to sound, developing a kind of memory patterns, considering acoustical and electromagnetically waves and involving cilia and microtubules and try to explain signal transduction.

nem

Both therapeutic options are associated with an activation of thrombogenic and fibrinolytic markers within 3 months of use. Tibolone appears to produce a better balance between thrombogenesis and fibrinolysis. Since our results show a lower incidence of thrombotic events, further studies are required.

APSTRAKTCilj. Utvrđivanje uticaja seksualnog ponašanja na obolevanje od karcinoma grlića materice kod žena u Srbiji i ispitivanje njihove povezanosti sa abnormalnim PAPA testom.Metod. Ispitivanje faktora seksualnog ponašanja za obolevanje od karcinoma grlića materice sprovedeno je po tipu studije preseka. Ispitivanu populaciju čini 525 pacijentkinja, starosti od 18 do 69 godina.Rezultati. Identifikovana su tri faktora rizika za abnormalan PAPA test: rana seksualna aktivnost, veći broj seksualnih partnera i SPB u anamnezi.Zaključak. Dobijeni rezultati ukazuju na potrebu uključivanja izabranih porodičnih lekara, kao i sestara i babica u patronažnoj službi domova zdravlja, u cilju identifikovanja populacije žena sa povećanim rizikom za obolevanje od cervikalnog karcinoma.Ključne reči: neoplazije grlića materice; Papanikolau test; seksualno ponašanje. ABSTRACTObjective. Determine risk factors for the incidence of cervical cancer in women in Serbia and testing their association with an abnormal Pap test.Method. The study of risk sexual behaviors of developing cervical cancer, carried out by the type of cross-sectional studies. The studied population is between 525 patients, aged 18 to 69 years.Results. We have identified three risk factors for an abnormal Pap test: early sexual activity, greater number of sexual partners and STDs in history.Conclusion. The results indicate the need for inclusion of selected family doctors and nurses and midwives in the Visiting Nurse Service of health, to recognition the population of women at increased risk of developing cervical cancer.