A brief review of the literature on the problem of double porphyria and analysis of its own observation is presented. For more than 10 years patient B was observed for more than 10 years with a verified diagnosis of acute intermittent porphyria, which manifested with acute pain abdominal syndrome, neurological disorders in the form of peripheral polyneuropathy and hemiparesis of lower extremities, and hypertension syndrome was also noted. The observed clinical symptoms corresponded to an acute porphyrin crisis in the manifestation and / or relapse of acute intermittent porphyria. The diagnosis was confirmed by a quantitative determination of the excretory profile of porphyrin precursors (δ-aminocaproic acid, porphobilinogen) and porphyrin fractions (uroporphyrin, coproporphyrin). Their concentrations are significantly (especially porphyrin precursors) exceeding the control values, which is the cardinal diagnostic criterion of acute intermittent porphyria. Against the backdrop of persistent clinical and biochemical remission of acute intermittent porphyria, symptoms of photosensitization of the skin (blisters, erosion, pigment spots) on the dorsal surface of the hands began to appear in 4 years. Later, hypertrichosis was formed in the temporo-periorbital region. The constellation type of the excretory profile of porphyrins began to change. Against the backdrop of persistent increased excretion of porphyrin precursors (δ-aminolevulinic acid and porphobilinogen), a progressive increase in the excretion of the fraction of uroporphyrin was observed, which became dominant (up to 58% of the total content of porphyrins). Such a prolonged observation in the dynamics allowed us to state the appearance of a new variant of the porphyrin exchange disturbance, which, taking into account clinical symptoms, corresponded to another form of hepatic porphyria, namely, late cutaneous porphyria. The clinical and biochemical changes in the excretory profile of the parameters of porphyrin metabolism registered in the dynamics of observation may indicate the occurrence of a combined enzymatic defect characteristic of double porphyria. In our case, a manifestation of late cutaneous porphyria was noted against a background of compensated acute intermittent porphyria.

In overcoming of antibiotic resistance in patients with chronic pruritic dermatoses, which often need lifelong monitoring and anti-inflammatory and antimicrobial therapy, topical using of shampoo with chlorhexidine 4% might be the optimal solution. Aim of research. To study the clinical efficacy of shampoo with chlorhexidine 4% (API-SAN, Russia) in dogs with chronic allergic dermatosis and secondary microbial diseases. Materials and methods. Experimental groups were formed: dogs with superficial pyoderma (1st), microbial pododermatitis (2nd) and malassesia dermatitis (3rd), as well as the control group. Results. In this study, we noticed that the pedigree and age sensitivity to dermatological problems was absent. The usual type of dog nutrition was not clearly correlated with the frequency of contacting with dermatologist. The result of the study was taken into account after the 14-day course of treatment in animals with an antimicrobial shampoo with 4 % chlorhexidine and was based in a decrease in the inflammatory (pruritus, skin erythema, exudation), reduction of lesions during planimetric measurement and detection of persistent restorative dynamics of the skin and hair. It was found that against the use of antimicrobial shampoo resistant clinical remission was observed within 7 days in the experimental groups and for 9-9.5 days in the control group. The clinical efficacy of anti-microbial shampoo with 4% chlorhexidine was shown by the results of negative сytology in the most of animals in the experimental groups.

This article presents a study of the effectiveness of the spray Fungin Forte (developed by LLC API-SAN) in the complex therapy of dermatophytosis in cats on a group of 20 animals infected spontaneously. Terbinafine in oral form in tablets was used as a fungicidal preparation and Fungin Forte samples in the form of a spray were used for local processing. The criteria for clinical efficacy were the results of an examination with a planimetry, which noted a reduction and change in the affected skin lesions, a decrease in the degree of itching (using a standard 10-point scale to assess itching), erythema, peeling, hair growth, and a negative mycological study conducted on DTM environment. The total therapeutic efficacy by the thirtieth day was 95 %, which allows the use of the spray as a local fungicide.

No abstract

The article presents the data on the clinical efficacy of ear gel «Osurnia» in 20 dogs weighing from 3 to 51 kg with the mixed microbial otitis externa cases at two-times instillation with an interval of 7 days with pre-treatment using cleaning lotion. The drug was studied in comparison with control three-component complex ear drops. The results of the studies were controlled clinically and cytologically after 7 and 14 days, respectively. Our experience has proved the high effectiveness of the drug «Osurnia» in regard to yeast and a coccial microbial. The significant influence of the preparation «Osurnia» on the chronic lichenisation and stenosis in the ear canal as well as the good tolerability «Osurnia» by all the animals are noted. Due to the rare administration of the drug the stress level in animals subjected to treatment is significantly reduced, as well as the risk of non-fulfillment of appointments by owners is minimized.