Introduction. Pregnant women are at a higher risk of a severe course of the coronavirus infection, including severe acute respiratory syndrome. They were identified as vulnerable groups with recommendations to take additional precautions since the onset of the COVID-19 pandemic. The aim of the study is to investigate the frequency and structure of risk factors for perinatal complications in women who contracted COVID-19 during pregnancy. Materials and methods. Analysis of clinical epidemiological and medical statistical data of the primary medical documentation (390 medical records) was carried out. The findings of 190 women who contracted COVID-19 during pregnancy (main group) were studied. We compared parameters of the test group with respective parameters of 200 women of the control group who did not contract COVID-19 during pregnancy. Age parameters, social status, somatic, reproductive and anamnesis data were investigated. Statistical processing of the results obtained was carried out using the package of application programs "Statistica 7.0" using the Excel 2013 standard package of statistical analysis. Credibility between different groups was examined based on the Pearson χ² test. Differences were considered plausible at a significance level of p<0.05. Results. The findings from the primary medical records of 190 women who contracted COVID-19 during pregnancy in 2021 were analyzed. The study has demonstrated that these women were significantly more often older than 36 years of age compared to the control group, they were significantly more likely to have complicated reproductive anamnesis: 28.4% vs. 10.5%, mainly based on all the parameters studied: spontaneous miscarriages, infertility and stillbirth (р<0.05). Somatic anamnesis in women of the main group was significantly more often burdened: 70.0% vs. 35.5%, p<0.05), due to the significant prevalence of endocrine pathology (14.2% vs. 5.0% in the control group), the cardiovascular disorders (10.0% vs. 4.0%, respectively), the urinary disorders (8.4% vs. 3.0%), and diseases of the respiratory system (18.0% vs. 1.5%) in women of the control group (р<0.05). Conclusion. The results obtained have shown that the risk factors for possible perinatal complications in women who contracted COVID-19 during pregnancy the most likely include the age over 36 years (13.5%), complicated reproductive anamnesis (28.4%), and the presence of somatic diseases (70.0%). Women who have contracted COVID-19 during pregnancy are at risk for obstetric complications.

The aim of the study was to determine the maternal factors of perinatal complications in women with diseases of the urinary system. A group of women with pathology of the urinary system were studied during the course and completion of pregnancy. The complications in childbirth condition of newborns in comparison with similar indicators in healthy women were also assessed. It was found that most women with urinary tract pathology that were pregnant again, had complications of somatic (most often a combination of urinary tract pathology and chronic infectious diseases) and reproductive history (most often – miscarriages). Women with complications during pregnancy, pyelonephritis, anemia, and the threat of abortion were significantly more often registered in the main group (p<0.05). Women in the main group were significantly more likely to have premature births: 15.4% of women with acute pyelonephritis and 46.2% of women with chronic pyelonephritis, while all women in the control group gave birth on time (P<0.05). Significantly more women in the main group had complications in childbirth: most often – weakness of labor – I group 8 (6.2%), II – 9 (6.9%). Termination of pregnancy in the vast majority of women in the main group was physiological, cesarean delivery was completed in 3 (2.3%) women in group I and 10 (7.7%) women in group II. All women in the control group had timely, physiological births. The condition of newborns of mothers with pathology of the urinary system was often disturbed. A significant proportion of children from the main group (I – 5.4%, II – 10.0%) required immediate resuscitation measures at birth and their transfer to specialized departments for further treatment.

The research aim is to study factors of perinatal complications among women with diseases of the urinary system on the basis of retrospective analysis of their newborns' condition. Materials and Methods. A total of 160 women with urinary diseases were selected for the study in Lviv Regional Clinical Hospital from 2014 to 2017. We studied the development of infants born to women with a clinical diagnosis of "Diseases of the urinary system". The newborns' gestational age at birth, anthropometric indicators, and condition assessment on the Apgar scale were analyzed. The obtained indicators were compared with similar parameters in the control group of healthy women that had given birth to live children in the same maternity department during the same period of time. Results and Discussion. We analyzed the condition of infants born to 130 women with urinary diseases. 68 of them were hospitalized with pyelonephritis, and 62 - with chronic pyelonephritis. The control group included 30 healthy female patients. The gestation age analysis showed that the number of preterm babies was higher in the group of infants born to mothers with acute pyelonephritis - 13 cases (10.0%) and even much higher in the group of mothers with chronic pyelonephritis - 25 cases (19.2%). These results were compared with the data obtained from the control group in which 30 full-term babies (100.0%) were born, (p <0.05). In the group of women with acute pyelonephritis, the majority of infants were born with the body weight more than 2500.0 g - 55 cases (42.3%), and 13 (10.0%) infants with the birth weight less than 2500.0 g. The mothers with chronic pyelonephritis gave birth to infants with the body weight less than 2500.0 g in 37 cases studied (28.5%). There was also a significant number of low birth weight newborns in this group - 25 cases (19.2%). In the control group, all 30 babies (100.0%) were born healthy weighing over 2500.0 g. Infants receiving less than 7 points on the Apgar scale were born to women with acute pyelonephritis in 15 cases (11.5%) and to mothers with chronic pyelonephritis in 25 cases (19.2%). In the group of healthy women, all newborns' condition was satisfactory. Conclusions. Women with urinary pathology are confirmed to be at risk of perinatal complications. The research has revealed the significant differences in gestational age, birth weight, and the Apgar score among infants born to women in the main and control groups (p<0.05). The infants whose mothers suffered from urinary pathology were often born prematurely: 13 (10.0%) - to mothers with acute pyelonephritis and 25 (19.2%) - to mothers with chronic pyelonephritis. At the same time the infants in the control group were born healthy (100.0%). Therefore, women with urinary pathology are recommended to be included in the "risk group" for perinatal complications.

The aim of the study was to analyse the reproductive function of women with miscarriages among the population of Lviv region. The data of the results of medical and genetic counseling of 120 women with miscarriages who visited the medical and genetic center and the “Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine” were analyzed. The obtained indicators were compared with similar parameters of the control group: 80 healthy women who asked for family planning consultation. A group of women with miscarriage was formed to study the features of menstrual function, somatic, reproductive and gynecological history in comparison with similar indicators in healthy women. It was found that the majority of women (47 (39.2%) with miscarriages were aged 31–15 years and 74 (61.6%) of women by social status were employees. 52 (48.0%) women of the main group had the onset of menarche significantly later – after 15 years old, in 25 (20.8%) of them the duration of the menstrual cycle was 28–85 days and in 11 (9.1%) – 35–55 days (p < 0.05). Women with miscarriages were significantly more likely to have a complicated somatic history and these are 86 (71.7%), mainly due to pathology of the cardiovascular system – 27 (22.5%), against 43 (53.75%) and 9 (11, 2%) (p <0.05), respectively. All of them 120 (100.0%) had significantly more frequent complications of reproductive and gynecological history due to miscarriages and stillbirths. In the control group this figure was 11 (13.7%) and 19 (23.8%) respectively (p<0.05).

Aim: to assess the risk of adverse consequences of adolescent pregnancy for mother and foetus in women from Lviv region. Material and methods. Complications of pregnancy and childbirth in adolescent women were studied retrospectively at the Lviv Regional Clinical Hospital. Results and discussion. 134 cases of adolescent childbirths for 2013 to 2017 were analyzed. The analysis of data on the course of pregnancy in adolescent women showed that the vast majority of them had complicated pregnancy and were at risk of preterm childbirth. A significant proportion of young women, 78 (58.2%), significantly more often required the therapy during pregnancy. Assessment of the health status of newborns showed that ¼ (24.6%) of young women gave birth to premature babies, and almost 1/3 of children, 51 (38.0%), from young mothers had a complicated early neonatal period. Within the spectrum of complications, the commonest diagnosis was "prematurity" in 33 (24.6%) children from young mothers. The pathological course of the early neonatal period in 51 (38.0%) children of the main group required transfer to other departments for further treatment. 82 (61.2%) children from this group were discharged home, while in the control group all 100 (100.0%) children were discharged from maternity home. Conclusions. The study has demonstrated that the risk factors for perinatal pathology in newborns from adolescent women included probably complicated pregnancy, risk of spontaneous abortion (17.9%), preterm birth (24.6%), and the childbirth of premature infants with impaired condition at birth, who needed treatment in other medical institutions (38.0%). Adolescent pregnant women are at risk for obstetric and perinatal complications.