Background: Substance abuse has become a serious issue that is faced by the world. The effects of drug abuse can be detrimental to corporeal, psychological and societal well-being of a person. Drug misuse is actually unrestrained habit of drugs leading to inspiration of reward-system in brain Substance abuse also influences the food preferences and dietary habits of the users, therefore affecting the person’s nutrition. Instead of how frequently a person engages in the behavior, substance abuse and substance addiction are distinguished by how challenging it is for the person to manage without the behavior or quit it for a specific period of time.  Methodology: Electronic databases were used to conduct a thorough, systematic analysis of research, which was restricted to those with English/English abstracts and used words like "addiction," "nutrition," "lifestyle," "alcohol," "reward system," "recreational substances," etc., Conclusion: An effort has been made in this research article to highlight the effects of various addictive substances on different systems in human body with the role of adequate nutrition to fight back this addiction for the overall betterment of the society.