BACKGROUND: Generic medicines offer an opportunity for governments to contain pharmaceutical expenditures, since generics are generally 10%-80% lower in price than brand medicines. Belgium has a small generic market that takes up 15% of the total pharmaceutical market in packages sold.

Our pilot survey showed that metastatic NSCLC patients in general are in favor of MT. They expect either an OS benefit of at least several months, or better symptom control, in balance with mild-to-moderate side effects.

Background: Patients with chronic health conditions risk aggravation of their health status due to reduced access to health services during the COVID-19 related lockdown.Objectives: To investigate the impact of Belgian COVID-19 measures on general health status (i.e. worse or stable/better) of patients, adult and pediatric, with chronic health conditions and how this change in health status relates to personal and health behavior-related factors.Design: A cross-sectional study using an online survey was conducted during the first COVID-19 related lockdown in Belgium.Methods: Associations between change in health status since the lockdown and (change in) personal and health behavior-related factors (including physical activity, access to healthcare services and social activities) were investigated.Results: In adults (n=561), almost all personal factors, including feelings of distress, depression, anxiety, somatization and low self-efficacy were significantly worse in patients with a worse health status during the lockdown (n=293, 52%) compared to patients reporting a stable/better health status (p<0.001 -0.002). Also, these patients reported lower physical activity levels, more teleconsultations and less social activities (p<0.001 -0.006). In children (n=55), all surveys were completed by a proxy (parent(s)/guardian) who reported a worse health status in 38% of the children. Level of distress of the child (p=0.005) since the lockdown and somatization of the parent(s) (p=0.0018) was significantly worse in children with a worse versus a stable/better health status.Conclusion: Fifty-two percent of the adults and 38% of children with chronic health conditions reported worsening of their general health status during the lockdown in March-May 2020 in Belgium. Negative personal factors and unhelpful health behavior seems to be associated with a worse health status.