Background The immigration of nurses in Iran is increasing day by day, and it seems work-related factors such as workload and healthy work environment are associated with the intention to immigration. Objectives this study was conducted to determine the intention to immigration in nurses and its relationship with workload and healthy work environment. Methods This cross-sectional, descriptive-correlational study was conducted in 2020 by simple random sampling method of 360 nurses working in hospitals in Iran. The study instruments were questionnaires of demographics, Intention to immigration (Lee, 2016), Workload (NASA-TLX) and healthy work environment (AACN, 2005). Data were analyzed by SPSS software and descriptive tests. p value < 0.05 was considered statistically signi cant. Results The score of intention to immigration was 65.59%, which indicated a high level of intention to immigration in nurses. There was a signi cant but weak correlation between intention to immigrate, with workload (r = 0.166, p = 0.002) and healthy work environment (r = 0.16, p = 0.002). Conclusion there was a weak but important relationship between the intention to immigration, workload and healthy work environment. More studies on factors related to the intention to immigration are required.