No abstract

This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.

Background: Coumarin is an important class of natural products with applications in different areas of knowledge. Due to its importance, several methodologies and strategies have been developed for the synthesis of different classes of compounds containing this nucleus. Objective: The aim of this review is to cover in the last five years the complex fused coumarin derivatives synthesized in one-pot three-component reactions. Conclusion: Considering that multicomponent reactions are a powerful tool to produce simple and complex compounds in one or few steps with high selectivity and yields while following the green chemistry principles.

The quinoline nucleus is a very important class of heterocyclic aromatic compounds present in several drugs on the market, with synthetic methodologies being necessary to prepare its nucleus and derivatives. Considering that fact, the aim of this review is to describe the development of eco-friendly methodologies for the synthesis of quinoline nucleus and its derivatives in the last five years. Thus, throughout the text are presented varios reagents and catalysts used in the synthesis of quinoline nucleus, the reaction conditions, the advantages of the described methodologies, along with the reaction scheme and some reaction mechanisms.

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.