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To probe the mechanism of mild hypothermia combined with rutin in the treatment of spinal cord injury (SCI). Methods: Thirty rats were randomized into the following groups: control, sham, model, mild hypothermia (MH), and mild hypothermia plus rutin (MH+Rutin). We used modified Allen's method to injure the spinal cord (T10) in rats, and then treated it with MH or/ and rutin immediately. BBB scores were performed on all rats. We used HE staining for observing the injured spinal cord tissue; ELISA for assaying TNF-α, IL-1β, IL-8, Myeloperoxidase (MPO), and Malondialdehyde (MDA) contents; Dihydroethidium (DHE) for measuring the reactive oxygen species (ROS) content; flow cytometry for detecting apoptosis; and both RT-qPCR and Western blot for determining the expression levels of TGF-β/Smad pathway related proteins (TGF-β, Smad2, and Smad3). Results: In comparison with model group, the BBB score of MH increased to a certain extent and MH+Rutin group increased more than MH group (p < 0.05). After treatment with MH and MH+Rutin, the inflammatory infiltration diminished. MH and MH+Rutin tellingly dwindled TNF-α, MDA and ROS contents (p < 0.01), and minified spinal cord cell apoptosis. MH and MH+Rutin could patently diminished TGF-β1, Smad2, and Smad3 expression (p < 0.01). Conclusion:MH+Rutin can suppress the activation of TGF-β/Smad pathway, hence repressing the cellular inflammatory response after SCI.

A desired total orientation workspace for a parallel manipulator is usually an essential requirement in a practical application. At present, for the multiobjective optimization method of 6-DOF parallel manipulator for desired total orientation workspace, it is needed to predefine maximal and minimal lengths of the legs to serve as the constraint, and then the numerical method is used to solve the length of the legs and judge whether the solved maximal and minimal leg lengths meet the constraint. Predefining maximal and minimal length of the legs limits of the optimal range, the numerical method has heavy calculation burden and low calculating accuracy. In this paper, a hybrid method for solving the maximal and minimal lengths of the legs of 6-DOF parallel manipulator with desired total orientation workspace is proposed, and the actuator stroke length is calculated according to the maximal and minimal leg lengths. By judging whether the actuator stroke length can be solved to serve as the constraint, without the predefined maximal and minimal leg lengths to serve as the constraint, the optimal range is enlarged. Aiming at the physical size of the parallel manipulator and the proposed desired workspace condition index (DWCI), the optimization of the geometric parameters of the parallel manipulator is conducted based on the multiobjective optimization algorithm (NSGA-II), which is subject to the actuator stroke length. Stewart platform is set as the example; the geometric parameters of the platform whose workspace contains the desired total orientation workspace are optimized and the hybrid method is proved to be more accurate and efficient compared to the traditional numerical method. This method provides the optimization guidance for engineering designers to design the parallel manipulator for desired total orientation workspace.

Lithium‐ion batteries (LIBs) play an important role in the storage of electrical energy in modern society, and there is an urgent need to develop anode materials that can meet the ever‐increasing demand for high energy density. The use of titanosilicate anode materials in high‐performance LIBs has attracted great attention due to their proper potential between graphite and Li4Ti5O12. A novel anode material prepared by an electrospinning method, orthorhombic Na2TiSiO5 (O‐NTSO) shows excellent cycle stability (capacity retention after 1000 cycles is 97.8%) and a usable reversible capacity (230 mAh g−1 at 50 mA g−1) with a safe average storage voltage of 0.8 V. The specific capacity of O‐NTSO is constituted by both capacitive and diffusion behavior. As a new member of the silicate anode materials, this orthorhombic Na2TiSiO5 has excellent electrochemical performance and is a promising LIB anode material with long cycle stability.

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