Herein, an amide oxygen-assisted palladium-catalyzed hydration reaction of alkynes is realized to prepare a series of o-acylacetanilide derivatives with high yield, and single regioselectivity under mild reaction conditions. This transformation is simple, practical, and can be performed on a gram scale. Evaluation of the mechanism shows that the reaction should involve an oxypalladation process, and the 1,3-oxazine compound is proven to be a key intermediate.

An efficient carboesterification of alkenes with anhydrides promoted by MnO2 has been developed to afford functionalized γ-lactones in good to excellent yields. This method shows a broad substrate scope and provides a valuable and convenient synthetic tool for constructing γ-lactones.

A series of novel 3-substituted-(thio)chroman-4-one derivatives 3a～3l were synthesized by the condensation of substituted (unsubstituted)-(thio)chromanone with aromatic aldehydes in the presence of sodium hydroxide, via two different methods of conventional solvent method and solvent-free grinding method which has advantages of simple work-up procedure, shorter reaction time, milder conditions and environ-mental friendliness. The structures of the title compounds 3a～3l were characterized by IR, 1 H NMR, 13 C NMR and MS techniques.

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