The current health information systems have many challenges such as lack of standard user interfaces, data security and privacy issues, inability to uniquely identify patients across multiple hospital information systems, probable misuse of patient data, high technological costs, resistance to technology deployments in hospital management, lack of data gathering, processing and analysis standardization. All these challenges, among others hamper either the acceptance of the health information systems, operational efficiency or expose patient information to cyber attacks. In this paper, an enhanced information systems success model for patient information assurance is developed using an amalgamation of Technology Acceptance Model (TAM) and Information Systems Success Model (ISS). This involved the usage of Linear Structured Relationship (LISREL) software to model a combination of ISS and Intention to Use (ITU), TAM and ITU, ISS and user satisfaction (US), and finally TAM and US. The sample size of 110 respondents was obtained based on the total population of 221 using the Conhrans formula. Thereafter, simple random sampling was employed to select members within each category of employees to take part in the study. The questionnaire as a research tool was checked for reliability via Cronbach’s Alpha. The results obtained showed that for ISS and ITU modeling, only perceived ease of use, system features, response time, flexibility, timeliness, accuracy, responsiveness and user training positively influenced the intention to use. However, for the TAM and ITU modeling, only TAM’s measures such as timely information, efficiency, increased transparency, and proper patient identification had a positive effect on intension to use. The ISS and US modeling revealed that perceived ease of use had the greatest impact on user satisfaction while response time had the least effect on user satisfaction. On its part, the TAM and US modeling showed that timely information, effectiveness, consistency, enhanced communication, and proper patients identification had a positive influence on user satisfaction.
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