Plasma cell features are encountered in a variety of non-plasma cell neoplasias, especially carcinomas of a discohesive type, such as those occurring in the digestive tract and breast. Lobular carcinomas of the breast present themselves in a variety of architectural patterns and many cell morphologies, including plasmacytoid types. A matching plasma cell phenotype is sometimes an associated feature. We report a case of a moderate grade invasive lobular carcinoma with focal plasmacytoid morphology and aberrant expression of plasma cell markers in a patient previously diagnosed with multiple myeloma. Paradoxical plasma cell immunoprofiles can be encountered in many malignancies, causing serious diagnostic problems, even more so with those occurring in discohesive carcinomas in multiple myeloma patients.

Dysgerminomas are a type of ovarian tumour which are developed from the germinal tissue and have a frequency of approximately 2% of all ovarian cancers. We report a case of a 40 years old female, which was admitted with abdominal pain and pollakiuria installed approximately 2 months ago. The particularity of the case lies in the late onset of the disease, compared to epidemiologic data, as well as in the immunohistochemical reactions, especially the negative PLAP reaction and positive CD30 reaction.

The basal cell carcinoma represents a worldwide major health problem due to incidence, functional and aesthetical defects which accompanies the disease and its treatment and high recurrency risk.The various morphoclinical forms of the basal cell carcinoma may be explained due to at least three factors: genetical predisposal, the individual immunological status and the action of the risk factors. In the case in which the histological aspects do present some modifications which cannot be catalogued in the usual patterns, therefore inseriated sections of the hole tumor being imposed, in order to establish correctly the diagnosis and in the case in which microscopical criteria are partially overposable with those specific to another lesion, the immunohistochemical evaluation is imposed.The immunohistochemical studies are also used in research, thus revealing some biological aspects of the basal cell carcinoma. The study of the biological markers of the apoptosis, cellullarproliferation and the immunitary system reaction allows the understanding of the morphofunctional anomalies during the neoplastic transformation process and the early identification of the aggressive forms.

Lichen sclerosus (LS) is a chronic mucocutaneous sclerosis most commonly affecting the genital area, although extragenital localizations have also been described1, with unknown pathogenesis. Our study aims to analyze the morphopathological aspects of LS through the prism of polarized microscopy and with the help of histochemical information provided by special Van Gieson stain for elastic tissue and Picro-Sirius Red special stain. Picro-Sirius Red staining allows observation of the type of collagen synthesized in pathological conditions such as LS, as well as the appearance of mature hyalinization through loss of elastic tissue, and also the disappearing of piloerectile muscles.

The use of the cell block in the cytology laboratory can be a routine procedure, having an important role in establishing the diagnosis and also in performing additional tests without the need for additional sampling of biological material. Numerous attempts have been made to modify and improve the cell block over the years, however, obtaining a cell block from a fluid biological product is a current challenge because lack of cell adhesion to a tissue remains the most common reason for dissatisfaction among cytopathologists. Although various methods for obtaining cell blocks have been proposed and described in the literature, it is noted that each of them has a disadvantage, in addition to advantages. Thus, in this study we propose a new method that eliminates in turn the disadvantages of other methods, obtaining an increase in cell densities, can apply additional testing applications, while minimizing laboratory costs.