There were examined 183 Uzbek patients with unstable angina. The basic group consisted of 125 patients with unstable angina (UA) and control group consisted of 58 healthy persons. Presence of CHD in family history among Uzbek patients with UA was associated with the accumulation of "damaging" alleles: "A" (M1-) G-A polymorphism of APOA1, "ε4" of APOE gene, and "D" I/D polymorphism of ACE gene. Meanwhile, there were no differences revealed in the frequency of carriage "T" allele of-516C/T polymorphism of APOB gene.