Objective. To evaluate the effect of the compliance in liver cancer patients with interventional therapy in the use of staged nursing intervention. Methods. A total of sixty liver cancer patients with interventional therapy were enrolled from January 2019 to December 2020. All patients were randomized to the control group (n = 30) and the experimental group (n = 30); routine nursing intervention and staged nursing intervention were conducted, respectively. The characteristics of compliance, psychological state, and other related indicators were recorded and compared. Results. The experimental group experienced lower VAS scores and higher treatment compliance. After intervention, both groups observed obvious reductions in the self-rating anxiety scale (SAS) scores, self-rating depression scale (SDS), and Pittsburgh Sleep Quality Index (PSQI) scores, while those were markedly lower in the experimental group (all P < 0.05 ). The experimental group yielded a significantly lower complication rate than the control group ( P < 0.05 ). Conclusion. In liver cancer patients with interventional therapy, staged nursing intervention could effectively relieve the pain, reduce the incidence of complications, and timely eliminate the negative emotion, thus playing a vital impact on the prognosis, worthy of further promotion.