Specific viral single and co-infections as well as viral load contribute to disease severity in children with LRTIs.

Simultaneous testing of respiratory viruses by real-time PCR is a suitable tool for the detection of viral coinfections. In children hospitalized because of respiratory infection viral coinfection is frequently detected with RSV and hBoV being a common combination.

Palivizumab-resistant respiratory syncytial virus was isolated from an infant treated with palivizumab. A stable mutation at codon 276 led to a nearly complete resistance to palivizumab. Additional studies revealed a second mutation at codon 272. Further passage of the virus led to a complete loss of binding of palivizumab.

Schmerztherapie in der PraxisRegelmäßiger Sonderteil der MMW, betreut von der Deutschen Migräne-und Kopfschmerzgesellschaft (DMKG) und der Deutschen Schmerzgesellschaft e.V.