Introduction: Traumatic Brain Injury is a case that is often encountered in emergency care installation and is one of the leading causes of death in the productive age range. Globally, the Traumatic Brain Injury incident increased sharply, mainly due to the increase in motorized vehicle use. In 2020,  the WHO estimated that traffic accidents would be the third-largest cause of disease and trauma in the world. In Indonesia, at Cipto Mangunkusumo Hospital Jakarta shows that the mortality rate is high in patients with severe head injuries with a percentage of 35% -50%. This figure is higher than the international literature standard. This study aims to describe the traumatic brain injury case in Wahidin Sudirohusodo Hospital from January 2016 - December 2017.Methods: This descriptive study report the evaluation of cases of traumatic brain injury patients at Wahidin Sudirohusodo Hospital Makassar, from January 2016 - December 2017. The population and sample are 1217 patients (total sampling).Result: From  1217 samples, most are men (70%), and 30% are women, with age 11-20 years are the most (30%). The most common causes of traumatic brain injury are caused by traffic accidents (89%). The largest group of patients (50%) had a mild head injury (GCS 14-15). From a Head CT scan, the most lesion was epidural hemorrhage (EDH) (26-34%) followed by intracerebral hemorrhage (ICH) (23-28%). About 36% patients were treated by operations and the rest were conservative. Based on the outcomes, about 77% were discharged from a hospital in life and 23% died.  Conclusion: The highest mortality was in severe head injury, about 87% was died (161 of 186 patients with a severe head injury). From the Head CT Scan, about 95% (19 of 20 patients) with IVH lesions were died and followed by ICH lesions as 39% (122 died from 309 patients). Based on the therapy given both surgery and conservative, patients who were discharged from the hospital in life at 77-79% and died 21-23%.

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