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Comprehensive follow-up care by experienced caregivers can be highly effective in reducing life-threatening illness without increasing costs among high-risk inner-city infants. JAMA. 2000;284:2070-2076.

Cytogenetic analysis was performed on 175 out of the 319 index cases (54 9 %). Of these, there were 161 trisomies (92%), 11 translocations (6 3 %), and three mosaics (17 %). Between 1969 and 1979 four terminations ofpregnancy for Down's syndrome were performed, all for trisomy.Quinquennial age specific incidences for Down's syndrome were calculated for the years

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