Ovarian cancer (OC) is the most malignant disease of the female reproductive system and accounts for a large proportion of gynecological cancer-related deaths. Emerging evidence has indicated that ginsenoside Rg3, one of the tetracyclic triterpenoid saponins in ginseng, plays crucial roles in regulating cancer progression, yet its role and mechanisms in regulating the proliferation and invasion of OC are still elusive. In this study, the cell viability, proliferation, migration and invasion of OC were assessed by using methyl thiazol tetrazolium (MTT), colony formation, wound healing and Transwell assays, respectively. The protein levels of E-cadherin and N-cadherin were analyzed by Western blot assay. The expression of long noncoding RNA (lncRNA) H19 was analyzed by quantitative real-time polymerase chain reaction (RT-qPCR). The results revealed that ginsenoside Rg3 significantly inhibited the viability of OC cells (SKOV3 and A2780) in a concentration‑dependent manner. Ginsenoside Rg3 (50 μg/ml) had almost no significant effect on the activity of human ovarian epithelial cells (HOSEpiCs). Thus, this dose was selected for the subsequent experiments. Furthermore, Rg3 markedly decreased the colony formation, migration and invasion of OC cells. In addition, the expression of N-cadherin was downregulated, and the expression of E-cadherin was upregulated with Rg3 treatment. Moreover, lncRNA H19 was upregulated in OC cells, and Rg3 negatively regulated H19 expression in a concentration-dependent manner. In terms of the mechanism, knockdown of H19 inhibited cell proliferation, migration and invasion, while overexpression of H19 reversed the inhibitory effect of Rg3 on the OC cells. In conclusion, ginsenoside Rg3 suppresses the proliferation, migration and invasion of OC cells by partially inhibiting the expression of lncRNA H19.

Background: Mutual assistance for the elderly is a new pension model that has been widely valued and discussed in China, especially in rural areas. The social and psychological capital owned by the elderly in rural areas promotes their participation and affects the realization of mutual assistance for the elderly. Based on this, this paper proposes the following hypotheses: H1: Bonding social capital positively affects the realization of mutual assistance for the elderly in rural areas; H2: bridging social capital positively affects the realization of mutual assistance for the elderly in rural areas; H3: linking social capital positively affects the realization of mutual assistance for the elderly in rural areas; and H4: psychological capital plays an intermediary role in the process of social capital influencing the realization of mutual assistance for the elderly in rural areas. The empirical research is carried out around these hypotheses. Methods: In this paper, the 2019 China General Survey of Social Conditions (CSS) database was used as the data source for empirical analysis. Social capital can be divided into bonding social capital, bridging social capital, and linking social capital, while psychological capital can be divided into four dimensions: self-efficacy, optimism, hope, and resilience. Our evaluation was performed using LOGIT regression analysis with STATA16 software. First, the correlation of social capital to the realization of mutual assistance for the elderly in rural areas was verified. Next, the mediation effect was verified using the KHB regression method, and the influence of psychological capital as an intermediary variable on the realization of mutual assistance for the elderly in rural areas was demonstrated. Results: Social capital had a significant positive effect on mutual assistance for the elderly in rural areas. Psychological capital played an intermediary role in the relationship between the three types of social capital and rural mutual assistance for the elderly. Among the four dimensions of psychological capital, self-efficacy, optimism, and tenacity played a partial mediating role in the relationship between social capital and mutual assistance for the elderly in rural areas, while the mediating role of hope was not significant. Conclusions: (1) All three types of social capital have a significant promoting effect on the realization of mutual assistance for the elderly in rural areas, among which bridging social capital has the most significant effect. (2) Psychological capital plays a partial mediating role in the three kinds of social capital’s influence on the realization of mutual assistance for the elderly in rural areas, and the intermediary role is the strongest in the effect of linking social capital on the realization of mutual assistance for the elderly in rural areas, but the overall effect is not high. (3) Among the four dimensions of psychological capital, self-efficacy, optimism, and tenacity all have certain intermediary effects, but the intermediary effect of hope is not significant. (4) There are significant gender and regional differences in the impact of social capital and psychological capital on the realization of mutual assistance for the elderly in rural areas.